dc.contributor.supervisor |
Arntfield, Susan (Food Science) Rempel, Curtis (Food Science) |
en_US |
dc.contributor.author |
Lagace, Melissa
|
|
dc.date.accessioned |
2012-09-07T14:32:17Z |
|
dc.date.available |
2012-09-07T14:32:17Z |
|
dc.date.issued |
2012-09-07 |
|
dc.identifier.uri |
http://hdl.handle.net/1993/8617 |
|
dc.description.abstract |
The effects of peptides derived from β-lactoglobulin and α-lactalbumin on metabolic syndrome were studied. α-lactalbumin and β-lactoglobulin were hydrolyzed with trypsin, alcalase, flavourzyme, or a combination of alcalase and flavourzyme and fractionated. Angiotensin coverting enzyme inhibition of the < 1 kDa fraction of alcalase hydrolyzed β-lactoglobulin was 95 %. Antioxidant activity of the < 1 kDa fraction of β-lactoglobulin hydrolyzed with a combination of alcalase and flavourzyme was 18 %. Stimulated adipocytes incubated with the < 1 kDa fraction of β-lactoglobulin hydrolyzed with either trypsin or alcalase produced 30 pg/mL of interleukin 6. Adiponectin and glucose transporter type 4 secretions increased 1.1 and 0.86 fold respectively during incubation with the < 1 kDa fraction of β-lactoglobulin hydrolyzed with a combination of alcalase and flavourzyme. Results indicate that β-lactoglobulin peptides formed with alcalase and a combination of alcalase and flavourzyme influence markers associated with metabolic syndrome and may be useful as functional foods or nutraceuticals. |
en_US |
dc.rights |
info:eu-repo/semantics/openAccess |
|
dc.subject |
metabolic |
en_US |
dc.subject |
whey |
en_US |
dc.subject |
inflammation |
en_US |
dc.subject |
hypertension |
en_US |
dc.subject |
diabetes |
en_US |
dc.subject |
hydrolysis |
en_US |
dc.subject |
syndrome |
en_US |
dc.subject |
lactalbumin |
en_US |
dc.subject |
lactoglobulin |
en_US |
dc.subject |
interleukin |
en_US |
dc.subject |
adipocyte |
en_US |
dc.subject |
macrophage |
en_US |
dc.subject |
glucose |
en_US |
dc.subject |
adiponectin |
en_US |
dc.subject |
alcalase |
en_US |
dc.subject |
flavourzyme |
en_US |
dc.subject |
trypsin |
en_US |
dc.subject |
oryzae |
en_US |
dc.subject |
lichenformis |
en_US |
dc.subject |
peptide |
en_US |
dc.title |
Effect of α-lactalbumin and β-lactoglobulin hydrolysates on markers of metabolic syndrome |
en_US |
dc.type |
info:eu-repo/semantics/masterThesis |
|
dc.degree.discipline |
Food Science |
en_US |
dc.contributor.examiningcommittee |
Scanlon, Martin (Food Science) Aluko, Rotimi (Human Nutritional Sciences) |
en_US |
dc.degree.level |
Master of Science (M.Sc.) |
en_US |
dc.description.note |
October 2012 |
en_US |