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dc.contributor.supervisor Arntfield, Susan (Food Science) Rempel, Curtis (Food Science) en_US
dc.contributor.author Lagace, Melissa
dc.date.accessioned 2012-09-07T14:32:17Z
dc.date.available 2012-09-07T14:32:17Z
dc.date.issued 2012-09-07
dc.identifier.uri http://hdl.handle.net/1993/8617
dc.description.abstract The effects of peptides derived from β-lactoglobulin and α-lactalbumin on metabolic syndrome were studied. α-lactalbumin and β-lactoglobulin were hydrolyzed with trypsin, alcalase, flavourzyme, or a combination of alcalase and flavourzyme and fractionated. Angiotensin coverting enzyme inhibition of the < 1 kDa fraction of alcalase hydrolyzed β-lactoglobulin was 95 %. Antioxidant activity of the < 1 kDa fraction of β-lactoglobulin hydrolyzed with a combination of alcalase and flavourzyme was 18 %. Stimulated adipocytes incubated with the < 1 kDa fraction of β-lactoglobulin hydrolyzed with either trypsin or alcalase produced 30 pg/mL of interleukin 6. Adiponectin and glucose transporter type 4 secretions increased 1.1 and 0.86 fold respectively during incubation with the < 1 kDa fraction of β-lactoglobulin hydrolyzed with a combination of alcalase and flavourzyme. Results indicate that β-lactoglobulin peptides formed with alcalase and a combination of alcalase and flavourzyme influence markers associated with metabolic syndrome and may be useful as functional foods or nutraceuticals. en_US
dc.subject metabolic en_US
dc.subject whey en_US
dc.subject inflammation en_US
dc.subject hypertension en_US
dc.subject diabetes en_US
dc.subject hydrolysis en_US
dc.subject syndrome en_US
dc.subject lactalbumin en_US
dc.subject lactoglobulin en_US
dc.subject interleukin en_US
dc.subject adipocyte en_US
dc.subject macrophage en_US
dc.subject glucose en_US
dc.subject adiponectin en_US
dc.subject alcalase en_US
dc.subject flavourzyme en_US
dc.subject trypsin en_US
dc.subject oryzae en_US
dc.subject lichenformis en_US
dc.subject peptide en_US
dc.title Effect of α-lactalbumin and β-lactoglobulin hydrolysates on markers of metabolic syndrome en_US
dc.degree.discipline Food Science en_US
dc.contributor.examiningcommittee Scanlon, Martin (Food Science) Aluko, Rotimi (Human Nutritional Sciences) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2012 en_US


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