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Systemic immune responses to intestinal-derived lipopolysaccharide (LPS) during subacute ruminal acidosis (SARA) and their possible role in innate immunity

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dc.contributor.supervisor Rodriguez-Lecompte, Juan Carlos (Animal Science) en_US
dc.contributor.author Kroeker, Angela
dc.date.accessioned 2012-09-06T19:53:11Z
dc.date.available 2012-09-06T19:53:11Z
dc.date.issued 2012-09-06
dc.identifier.uri http://hdl.handle.net/1993/8611
dc.description.abstract The effects of induced subacute ruminal acidosis (SARA) using grain pellet-based (GPI) and alfalfa pellet-based diet models on systemic immunological parameters were evaluated in nonlactating Holstein cows. The systemic immunological parameters analysed in this study included rectal temperature, blood cell leukogram, expression of lipopolysaccharide (LPS) recognition receptors on leukocytic cells, and plasma and serum proteins. Also, blood biochemistry was analysed. There were no significant differences in rectal temperature, blood cell leukogram, expression of LPS recognition receptors and fibrinogen or haptoglobin concentrations between control and SARA induction treatments. Concentrations of serum amyloid A and lipopolysaccharide-binding protein increased while total protein concentrations decreased in response to GPI SARA compared to control. Blood glucose and urea concentrations increased and decreased, respectively, with GPI SARA treatment. Grain pellet-induced SARA resulted in changes to serum proteins and acute phase proteins but did not affect other systemic immunological parameters suggesting a localized inflammatory response was initiated. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Subacute ruminal acidosis en_US
dc.subject Lipopolysaccharide en_US
dc.subject CD14 en_US
dc.title Systemic immune responses to intestinal-derived lipopolysaccharide (LPS) during subacute ruminal acidosis (SARA) and their possible role in innate immunity en_US
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Animal Science en_US
dc.contributor.examiningcommittee Plaizier, Kees (Animal Science) Ominski, Kim (Animal Science) O, Karmin (Animal Science) Holley, Rick (Food Science) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2012 en_US


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