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dc.contributor.supervisor Roksandic, Mirjana (Anthropology) en_US
dc.contributor.author Armstrong, Stephanie D.
dc.date.accessioned 2012-08-23T14:38:30Z
dc.date.available 2012-08-23T14:38:30Z
dc.date.issued 2012-08-23
dc.identifier.uri http://hdl.handle.net/1993/8459
dc.description.abstract Health in archaeological populations needs to be investigated using a holistic approach. Molecular techniques, particularly multiplex PCR, can be used with paleopathology and dietary analysis to understand aspects of population health. This thesis demonstrates how spina bifida, a multi-factorial disease, can be investigated using this paleoepidemiological approach. Based on skeletal evidence, spina bifida was present in a pre-Columbian Cuban population from the archaeological site of Canimar Abajo. Molecular techniques were employed to examine disease potential, examining individuals for five single nucleotide polymorphisms associated with spina bifida. It is postulated that the combined effect of these polymorphisms, as well as dietary factors, determines the risk of the population for spina bifida, and that these factors came together to create the observed high disease prevalence. Therefore, this thesis demonstrates how the methods of molecular paleopathology, corroborated by dietary analyses, can be used within a paleoepidemiological framework to understand population health and disease. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject paleopathology en_US
dc.subject paleoepidemiology en_US
dc.subject spina bifida en_US
dc.subject Cuba en_US
dc.subject single nucleotide polymorphisms en_US
dc.subject folate en_US
dc.title Spina bifida at a pre-Columbian Cuban site: a molecular and paleoepidemiological perspective en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Anthropology en_US
dc.contributor.examiningcommittee Hoppa, Robert (Anthropology) Matheson, Carney (Lakehead University) en_US
dc.degree.level Master of Arts (M.A.) en_US
dc.description.note October 2012 en_US


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