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dc.contributor.supervisor Halayko, Andrew (Physiology) en_US
dc.contributor.author Hynes, Tyler
dc.date.accessioned 2012-05-15T19:36:20Z
dc.date.available 2012-05-15T19:36:20Z
dc.date.issued 2012-05-15
dc.identifier.uri http://hdl.handle.net/1993/6206
dc.description.abstract Allergic asthma is a syndrome characterized by respiratory distress in response to environmental triggers. This atypical response to an allergen is an over reaction of the immune system causing an influx of inflammatory cells into the airway and concomitant airway smooth muscle constriction. Firstly, we demonstrate using whole house dust mite (HDM) extract as a sensitizing allergen produces an equivalent or more robust hyperresponsive and inflammatory reaction than can be achieved with the widely used ovalbumin (OVA) sensitization / challenge protocol. Secondly, we investigated the role of caveolin-1 in the pathophysiology of allergic asthma . Our data suggest an important role for cav-1 in down regulating allergic airway inflammation, leading to reduced airways hyperresponsiveness and mucus overproduction. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject caveolin-1 en_US
dc.subject asthma en_US
dc.subject hyperresponsiveness en_US
dc.subject airway en_US
dc.subject inflammation en_US
dc.subject physiology en_US
dc.title Role of caveolin-1 in airway hyper-responsiveness and inflammation in response to house dust mite challenge en_US
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Physiology en_US
dc.contributor.examiningcommittee Bshouty, Zoheir (Physiology) Kroeger, Ed (Physiology) Peng, Zhikang (Immunology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2012 en_US


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