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dc.contributor.supervisor Pierce, Grant (Physiology) en_US
dc.contributor.author McCullough, Richelle Stephanie
dc.date.accessioned 2012-04-12T20:26:45Z
dc.date.available 2012-04-12T20:26:45Z
dc.date.issued 2011-11 en_US
dc.identifier.citation Lipids Volume 46, Number 11, 1043-1052 en_US
dc.identifier.uri http://hdl.handle.net/1993/5303
dc.description.abstract Dietary flaxseed has cardioprotective effects that may be achieved through its rich content of the omega-3 fatty acid, alpha linolenic acid (ALA). We investigated the effects of dietary flaxseed both with and without an atherogenic cholesterol-enriched diet to determine the effects of dietary flaxseed on the expression of the adipose cytokines leptin and adiponectin. Rabbits were fed one of four diets: a regular (RG) diet, or a regular diet with added 0.5% cholesterol (CH), or 10% ground flaxseed (FX), or both (CF) for 8 weeks. Levels of leptin and adiponectin expression were assessed by RT-PCR in visceral adipose tissue. Consumption of flaxseed significantly increased plasma and adipose levels of ALA. Leptin, but not adiponectin, mRNA expression was lower in CH animals and was elevated in CF animals. Changes in leptin expression were strongly and positively correlated with adipose ALA levels and inversely correlated with levels of en face atherosclerosis. Our data demonstrate that the type of fat in the diet as well as its caloric content can specifically influence leptin expression. The findings support the hypothesis that the beneficial cardiovascular effects associated with flaxseed consumption may be related to a change in leptin expression. en_US
dc.publisher Springer en_US
dc.subject adipose en_US
dc.subject adipokines en_US
dc.subject leptin en_US
dc.subject CRP en_US
dc.subject dietary en_US
dc.subject flaxseed en_US
dc.title Dietary flaxseed supplementation and the expression of adipokines en_US
dc.degree.discipline Physiology en_US
dc.contributor.examiningcommittee Zahradka, Peter (Physiology) Gilchrist, James (Oral Biology) Anderson, Hope (Pharmacy) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note May 2012 en_US


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