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dc.contributor.supervisor Aukema, Harold (Human Nutritional Sciences) Tappia, Paramjit (Human Nutritional Sciences) en_US
dc.contributor.author Prairie, Natalie Paula
dc.date.accessioned 2012-01-03T17:42:58Z
dc.date.available 2012-01-03T17:42:58Z
dc.date.issued 2012-01-03
dc.identifier.uri http://hdl.handle.net/1993/5015
dc.description.abstract Pea protein hydrolysate (PPH) has antihypertensive effects and prostanoids have been implicated in renal diseases. To investigate the role of PPH and prostanoids on renal and cardiovascular effects in cardio-renal disease, normal and diseased Han:SPRD-cy rats were given diets containing either 0, 0.5% or 1% PPH for 8 weeks. At termination, diseased rat kidneys displayed increased renal cyst growth, fibrosis, plasma creatinine and lower monocyte chemoattractant protein-1. Diseased rats also exhibited left ventricular (LV) hypertrophy, elevated systolic and diastolic blood pressures and LV end diastolic and systolic pressures. Four of five prostanoids were elevated in diseased rat kidneys. PPH attenuated systolic blood pressure, but not other components of the cardio-renal syndrome. PPH also increased select prostanoids in normal and diseased rats. Thus, dietary PPH attenuates hypertension in the Han:SPRD-cy rat, but does not ameliorate other components of disease, possibly due to increased prostanoid effects or an insufficient treatment length. en_US
dc.subject pea protein hydrolysate en_US
dc.subject Han:SPRD-cy rat en_US
dc.subject chronic kidney disease en_US
dc.subject angiotensin converting enzyme en_US
dc.subject renin en_US
dc.title The cardio-renal effect of pea protein hydrolysate in a chronic kidney disease rat model en_US
dc.degree.discipline Human Nutritional Sciences en_US
dc.contributor.examiningcommittee Zahradka, Peter (Human Nutritional Sciences) Kirshenbaum, Lorrie (Physiology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2011 en_US


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