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dc.contributor.supervisor Kumar, Anand (Medical Microbiology) en_US
dc.contributor.author Meghairbi, Khaleel
dc.date.accessioned 2011-12-21T15:35:32Z
dc.date.available 2011-12-21T15:35:32Z
dc.date.issued 2011-12-21
dc.identifier.uri http://hdl.handle.net/1993/5004
dc.description.abstract Septic shock and sepsis associated multiple organ failure are a major cause of morbidity and mortality in intensive care units (ICUs) globally. The treatment of patients with septic shock remains one of the major challenges to ICU clinicians. In this research, 342 bacteremic patients with septic shock were determined to have been treated with a β-lactam monotherapy. Objective: To show that key pharmacokinetic indices for a wide variety of β–lactams are associated with outcome in human septic shock. Methods: β-lactam pharmacodynamic (PD) indices including time above MIC and four times above MIC (ƒT>MIC, ƒT>4X MIC). Logistic regression analysis of 1st 24 hour time above MIC (p=.0005) and 1st 24 hour time above 4X MIC (p=.0003) were strongly associated with the improved survival of septic shock. Neither the 1st 24 hour Cpeak/MIC (p=.0762) or 1st 24 hour AUC/MIC (p=.0872) achieved significance in relation to outcome in logistic regression analysis. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Clinical en_US
dc.subject Microbiology en_US
dc.title The association of antibiotic pharmacodynamic indices with survival in human septic shock en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Medical Microbiology en_US
dc.contributor.examiningcommittee Alfa, Michelle (Medical Microbiology) Zhanel, George (Medical Microbiology) Zelenitsky, Sheryl (Pharmacy) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2012 en_US


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