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The effect of galanin alone and combined with estrogen in a cuprizone-induced demyelination mouse model of multiple sclerosis

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dc.contributor.supervisor Vrontakis, Maria (Human Anatomy and Cell Science) Kong, Jiming (Human Anatomy and Cell Science) en_US
dc.contributor.author Zhang, Lin
dc.date.accessioned 2011-08-09T17:47:15Z
dc.date.available 2011-08-09T17:47:15Z
dc.date.issued 2011-08-09
dc.identifier.uri http://hdl.handle.net/1993/4749
dc.description.abstract Multiple Sclerosis (MS) is an autoimmune demyelination disease of the central nervous system (CNS). The traditional immunotherapies so far have not been able to stop the progression of the disease. Galanin (GAL) is an inducible neuropeptide. It has diverse regulatory effects in the nervous. The expression of galanin is induced by the administration of estrogen and is increased during pregnancy in rodents. In women with MS, pregnancy has a protective effect associated with significant remission of MS symptoms during the second and third trimester. In this study, using the cuprizone (CPZ) demyelination model of MS I demonstrated that GAL has a pronounced neuroprotective effect on demyelination and remyelination, with estrogen the protection was further enhanced. Moreover, I also found differential activation of GAL receptors in the demyelination and remyelination processes. These results suggest GAL alone or combined with estrogen might introduce next generation strategies for the treatment of MS. en_US
dc.subject Multiple sclerosis en_US
dc.subject galanin en_US
dc.subject estrogen en_US
dc.subject cuprizone en_US
dc.subject demyelination en_US
dc.subject remyelination en_US
dc.title The effect of galanin alone and combined with estrogen in a cuprizone-induced demyelination mouse model of multiple sclerosis en_US
dc.degree.discipline Human Anatomy and Cell Science en_US
dc.contributor.examiningcommittee Parkinson, Fiona (Pharmacology and Therapeutics) VBergen, Hugo (Human Anatomy and Cell Science) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2011 en_US


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