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dc.contributor.supervisor Ball, T. Blake (Medical Microbiology) en
dc.contributor.author Chan, Mable W. S.
dc.date.accessioned 2011-04-12T16:06:10Z
dc.date.available 2011-04-12T16:06:10Z
dc.date.issued 2011-04-12T16:06:10Z
dc.identifier.uri http://hdl.handle.net/1993/4522
dc.description.abstract The importance of arenavirus glycoprotein processing has only been understood within the past decade, with the majority of work focused on the Old World arenaviruses. Evidence has shown that SKI-1/S1P (subtilisin kexin isozyme-1/site 1 protease) is the cellular protease responsible for glycoprotein cleavage in Old and New World arenaviruses. Furthermore, glycoprotein cleavage is shown to be necessary for the production of infectious virus particles in Lassa and Junín viruses. In this thesis, evidence is provided that the recently emerged Chapare virus (New World) is also processed by SKI-1/S1P. Additionally, novel serpin-based SKI-1 inhibitors were shown to effectively prevent SKI-1 mediated cleavage. Using a wide panel of recombinant vesicular stomatitis viruses expressing New World arenavirus glycoproteins, these inhibitors were capable of significantly reducing viral titres. This provides strong evidence that SKI-1 inhibitors can be used as an effective treatment against the majority of New World Clade B arenaviruses and LASV in vivo. en
dc.format.extent 1777786 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject arenaviruses en
dc.subject glycoprotein en
dc.subject serpin en
dc.subject SKI-1 en
dc.title Serpin-based SKI-1/S1P inhibitors against Old and New World arenaviruses en
dc.degree.discipline Medical Microbiology en
dc.contributor.examiningcommittee Stetefeld, Jorg (Chemistry) Fowke, Keith (Medical Microbiology) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note May 2011 en


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