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dc.contributor.supervisorBridges, Greg (Electrical and Computer Engineering)en
dc.contributor.authorSalimi, Elham
dc.date.accessioned2011-04-07T19:30:17Z
dc.date.available2011-04-07T19:30:17Z
dc.date.issued2011-04-07T19:30:17Z
dc.identifier.urihttp://hdl.handle.net/1993/4460
dc.description.abstractNanosecond pulse electroporation of biological cells is gaining significant interest due to its ability to influence intracellular structures. In nanosecond pulse electroporation of biological cells nanosecond duration pulses with high frequency spectral content are applied to the cell. In this research we show that accurate modeling of the nanosecond pulse electroporation process requires considering the effect of the membrane dielectric relaxation on the electric potential across the membrane. We describe the dielectric relaxation of the membrane as dispersion in the time-domain and incorporate it into the nonlinear asymptotic model of electroporation. Our nonlinear dispersive model of a biological cell is solved using finite element method in 3-D space enabling arbitrary cell structures and internal organelles to be modeled. The simulation results demonstrate two essential differences between dispersive and non-dispersive membrane models: the process of electroporation occurs faster when the membrane dispersion is considered, and the minimum required electric field to electroporate the cell is significantly reduced for the dispersive model.en
dc.format.extent681020 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectElectroporationen
dc.subjectDielectric dispersionen
dc.subjectDebye relaxation modelen
dc.titleNanosecond pulse electroporation of biological cells: The effect of membrane dielectric relaxationen
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineElectrical and Computer Engineeringen_US
dc.contributor.examiningcommitteeThomson, Douglas (Electrical and Computer Engineering) Lin, Francis (Physics and Astronomy)en
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteMay 2011en


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