Show simple item record

dc.contributor.supervisor Czubryt, Michael (Physiology) en
dc.contributor.author Ramjiawan, Angela
dc.date.accessioned 2010-09-10T23:04:04Z
dc.date.available 2010-09-10T23:04:04Z
dc.date.issued 2010-09-10T23:04:04Z
dc.identifier.uri http://hdl.handle.net/1993/4160
dc.description.abstract PGC-1α regulates cardiac mitochondrial biogenesis and energy metabolic gene expression, thus transcriptional regulation of PGC-1α gene expression is of great importance in understanding metabolic gene expression in cardiac health and disease. We provide evidence that estrogen related receptor α (ERRα, which also plays a role in cardiac energy metabolism, regulates expression of the PGC-1α gene via direct interaction with the PGC-1α gene promoter. In the presence of an inverse agonist to ERRα PGC-1α gene expression was significantly decreased, while over-expression of ERRα increased PGC-1α gene expression. We have also demonstrated that expression of PGC-1α was down regulated in hypoxic cardiomyocytes due to histone deacetylation. Our data identify ERRα as a novel regulator of cardiac PGC-1α gene expression, and suggests that promoter deacetylation in hypoxia plays a role in reduced PGC-1α expression. These results reveal a new mechanism that may contribute to energetic derangement in the heart during ischemia and/or failure. en
dc.format.extent 682934 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Cardiovascular Physiology en
dc.subject Molecular Pathophysiology en
dc.title Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter en
dc.degree.discipline Physiology en
dc.contributor.examiningcommittee Dixon, Ian (Physiology) Jassal, Davinder (Medicine) Mesaeli, Nasrin (Biochemistry and Medical Genetics) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note October 2010 en


Files in this item

This item appears in the following Collection(s)

Show simple item record

View Statistics