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dc.contributor.supervisor Namaka, Michael(Faculty of Pharmacy) en
dc.contributor.author BEGUM, FARHANA
dc.date.accessioned 2010-09-10T21:15:36Z
dc.date.available 2010-09-10T21:15:36Z
dc.date.issued 2010-09-10T21:15:36Z
dc.identifier.uri http://hdl.handle.net/1993/4140
dc.description.abstract Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Antigen induced activation of Th1 cells in the peripheral blood leads to elevated production of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) that have been directly linked to disease induction and neuropathic pain. It was hypothesized that following antigenic induction, cytokines gain access to the spinal cord and participate in direct cellular interaction with dorsal horn neurons. Using an animal model of MS, we show that TNF-α gene and protein expression in the dorsal root ganglia (DRG) and spinal cord tissue is increased in the active group. In addition, our findings show TNF-α mRNA expression in the dorsal root entry point. Therefore, our results support the hypothesis that antigen induced DRG derived TNF-α can transport to the spinal cord via the dorsal roots and is involved in the underlying pathogenesis of MS induced neuropathic pain. en
dc.format.extent 4138516 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject MULTIPLE SCLEROSIS en
dc.subject NEUROPATHIC PAIN en
dc.subject TUMOR NECROSIS FACTOR ALPHA en
dc.title MULTIPLE SCLEROSIS INDUCED NEUROPATHIC PAIN en
dc.degree.discipline Human Anatomy and Cell Science en
dc.contributor.examiningcommittee Frost, Emma (Faculty of Pharmacy), Klonisch, Thomas (Human Anatomy and Cell Science) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note October 2010 en


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