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dc.contributor.supervisorNamaka, Michael(Faculty of Pharmacy)en
dc.contributor.authorBEGUM, FARHANA
dc.date.accessioned2010-09-10T21:15:36Z
dc.date.available2010-09-10T21:15:36Z
dc.date.issued2010-09-10T21:15:36Z
dc.identifier.urihttp://hdl.handle.net/1993/4140
dc.description.abstractMultiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). Antigen induced activation of Th1 cells in the peripheral blood leads to elevated production of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) that have been directly linked to disease induction and neuropathic pain. It was hypothesized that following antigenic induction, cytokines gain access to the spinal cord and participate in direct cellular interaction with dorsal horn neurons. Using an animal model of MS, we show that TNF-α gene and protein expression in the dorsal root ganglia (DRG) and spinal cord tissue is increased in the active group. In addition, our findings show TNF-α mRNA expression in the dorsal root entry point. Therefore, our results support the hypothesis that antigen induced DRG derived TNF-α can transport to the spinal cord via the dorsal roots and is involved in the underlying pathogenesis of MS induced neuropathic pain.en
dc.format.extent4138516 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMULTIPLE SCLEROSISen
dc.subjectNEUROPATHIC PAINen
dc.subjectTUMOR NECROSIS FACTOR ALPHAen
dc.titleMULTIPLE SCLEROSIS INDUCED NEUROPATHIC PAINen
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineHuman Anatomy and Cell Scienceen_US
dc.contributor.examiningcommitteeFrost, Emma (Faculty of Pharmacy), Klonisch, Thomas (Human Anatomy and Cell Science)en
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteOctober 2010en


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