Show simple item record

dc.contributor.supervisor Uzonna, Jude (Immunology) en
dc.contributor.author Muleme, Helen
dc.date.accessioned 2010-04-08T19:47:34Z
dc.date.available 2010-04-08T19:47:34Z
dc.date.issued 2010-04-08T19:47:34Z
dc.identifier.citation Muleme HM, Reguera RM, Berard A, Azinwi R, Jia P, Okwor IB, Beverley S, Uzonna JE (2009). Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis, Journal of Immunology 183(12):8068-76 en
dc.identifier.uri http://hdl.handle.net/1993/3920
dc.description.abstract The outcome of infection with Leishmania major depends in part on the balance between arginase and inducible nitric oxide synthase in macrophages. These enzymes compete for the substrate L-arginine. Leishmania major also encodes an arginase gene but, the role of this parasite-derived enzyme in infection remains unclear. We hypothesize that parasite-derived arginase influences parasite survival and host immune response to L. major. To examine this hypothesis, we employed an arginase deficient null mutant L. major in in vitro and in vivo experiments. Our results show that deficiency of parasite-derived arginase impaired parasite proliferation and disease pathogenesis. Increased arginase activity however neither affected nitric oxide production, nor did it correlate with IL-4 production. Primary infection of normally resistant hosts causes a chronic infection and does not protect them against re-infection. Thus, parasite-derived arginase is of nutritional importance to L. major, but is not a feasible therapeutic drug target. en
dc.format.extent 1547869 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject arginase en
dc.subject leishmaniasis en
dc.subject immunoparasitology en
dc.title The role of parasite-derived arginase in murine Leishmania major en
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Immunology en
dc.contributor.examiningcommittee Soussi Gounni, Abdel (Immunology) Wilkins, John (Biochemistry and Medical Genetics) Anderson, Robert (University of Winnipeg) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note May 2010 en


Files in this item

This item appears in the following Collection(s)

Show simple item record

View Statistics