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dc.contributor.supervisor Labossiere, Paul (Mechanical and Manufacturing Engineering) en_US
dc.contributor.author Friesen, Lauren
dc.contributor.author Katona, Brad
dc.contributor.author Desilets, Lucien
dc.contributor.author Leslie, Anthony
dc.date.accessioned 2021-05-17T15:48:47Z
dc.date.available 2021-05-17T15:48:47Z
dc.date.issued 2015-12-07
dc.identifier.uri http://hdl.handle.net/1993/35615
dc.description.abstract The team was presented with a design problem by Emergent BioSolutions requiring the design of a single-use chromatography column to be used for processing blood plasma. The column that is currently used is very heavy and bulky and made with entirely reusable components meaning that it must be fully sanitized between each use. Emergent BioSolutions wishes to be able to perform chromatography in a mobile environment but these factors make the current column unsuitable for this application. Therefore, the new column must, most importantly, feature a single-use flow path for the plasma, which will reduce the need to completely sanitize the column. It must also be lightweight, cost effective, and composed of primarily commercially available compliant materials. Furthermore, the design must be simple to assemble and adhere to the same chromatography procedure currently performed by the client. In order to solve this design problem, the team worked closely with the client to define the design problem and project requirements. The team then generated a series of conceptual designs and was able to determine the most suitable design using developed scoring criteria. The flow path consists of a disposable liner that is supported by a reusable, rigid tank. Thus, although the final design has a final cost of $2920.37, the cost per use following its initial construction is $1432.57 due to the liner and therefore is extremely cost effective relative to Emergent BioSolutions’ current design. en_US
dc.description.sponsorship Emergent BioSolutions en_US
dc.rights info:eu-repo/semantics/openAccess
dc.title Design of a Mobile, Single-Use Chromatography Column en_US
dc.type Report en_US
dc.type info:eu-repo/semantics/report
dc.degree.discipline Mechanical Engineering en_US
dc.contributor.examiningcommittee DeGagne, Bill (Mechanical and Manufacturing Engineering) en_US
dc.degree.level Bachelor of Science (B.Sc.) en_US


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