Rational approach towards the design of netrin- 1/UNC5 and netrin-1/DCC interaction inhibitors
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Date
2019-04-25
Authors
Wang, Guanyu
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Abstract
This study mainly focuses on the rational design, synthesis and bioassay testing of netrin-1/UNC5 and netrin-1/DCC inhibitors. This study began with the development of a virtual screening method to select out candidates from virtual libraries. These candidates were then synthesized and the binding affinity between the synthesized molecules and netrin-1 was evaluated by microscale thermophoresis.
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Keywords
netrin-1, DCC, UNC5, Rational Design, Drug Design