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dc.contributor.supervisor Aukema, Harold (Food and Human Nutritional Sciences) en_US
dc.contributor.author Ferdouse, Afroza
dc.date.accessioned 2019-01-08T20:25:50Z
dc.date.available 2019-01-08T20:25:50Z
dc.date.issued 2019-01-02 en_US
dc.date.submitted 2019-01-03T18:05:20Z en
dc.identifier.uri http://hdl.handle.net/1993/33665
dc.description.abstract Although the effects of dietary polyunsaturated fatty acids (PUFA) are well-known in the heart and brain, little is known about oxylipins, their bioactive lipid metabolites. To provide fundamental data on these oxylipin profiles, and the effects of dietary PUFA and sex on these profiles, weanling female and male Sprague-Dawley rats were given diets modified in oil composition to provide higher levels of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid or linoleic acid, compared to control diets. Dietary PUFA mainly altered the levels of their own oxylipins, but also affected others. N-6 PUFA derived oxylipins were reduced by dietary n-3 PUFA in the heart, but not the brain, which generally was less resistant to diet-induced changes in oxylipins. Oxylipins were generally higher in females in heart but higher in males in brain. These data provide fundamental data that will inform studies on the roles of oxylipins in heart and brain. en_US
dc.subject Oxylipins en_US
dc.subject Eicosanoids en_US
dc.subject dietary fat en_US
dc.subject ALA en_US
dc.subject EPA en_US
dc.subject DHA en_US
dc.subject LA en_US
dc.subject ARA en_US
dc.subject Heart en_US
dc.subject Brain en_US
dc.subject Sex en_US
dc.title Effects of dietary n-3 and n-6 fatty acids and sex on the heart and brain oxylipin profiles in healthy rats en_US
dc.degree.discipline Food and Human Nutritional Sciences en_US
dc.contributor.examiningcommittee Moghadasian, Mohammed (Food and Human Nutritional Sciences) Mizuno, Tooru (Physiology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2019 en_US


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