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Maternal resveratrol supplementation in gestational diabetes prevents cardio-metabolic disease development and improves cardiac structure in the rat offspring

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dc.contributor.supervisor Dolinsky, Vernon (Pharmacology and Therapeutics) en_US
dc.contributor.author Brawerman, Gabriel Martin
dc.date.accessioned 2019-01-07T19:07:35Z
dc.date.available 2019-01-07T19:07:35Z
dc.date.issued 2018 en_US
dc.date.submitted 2018-11-29T22:17:10Z en
dc.date.submitted 2019-01-07T15:57:38Z en
dc.identifier.uri http://hdl.handle.net/1993/33633
dc.description.abstract Gestational diabetes mellitus (GDM), a common complication of pregnancy, arises during the third trimester and is characterized by hyperglycemia. GDM increases cardio-metabolic disease risk in mothers and offspring. Current treatments have disadvantages. Resveratrol (RESV), a naturally produced polyphenol, has anti-oxidant and positive metabolic health effects. Thus, we hypothesized that RESV supplementation during the third trimester and lactation would improve maternal glucose tolerance and prevent cardio-metabolic disease in the offspring. A diet-induced GDM model was utilized for this thesis. Different metabolic tests were performed. Echocardiography was used to assess cardiac structure and function. Immunoblotting, qPCR and cardiomyocyte isolations were performed to study mechanisms. RESV supplementation prevented maternal glucose intolerance and cardio-metabolic disease development in the offspring by improving glucose homeostasis and inhibiting cardiac remodelling. Supplementing maternal diets with RESV at the onset of GDM may become a newer intervention to protect mothers and their offspring from GDM-induced short and long-term consequences. en_US
dc.subject Gestational diabetes mellitus en_US
dc.subject Resveratrol en_US
dc.subject Developmental origins of health and disease en_US
dc.subject Offspring health en_US
dc.subject Cardio-metabolic disease en_US
dc.title Maternal resveratrol supplementation in gestational diabetes prevents cardio-metabolic disease development and improves cardiac structure in the rat offspring en_US
dc.degree.discipline Pharmacology and Therapeutics en_US
dc.contributor.examiningcommittee Hatch, Grant (Pharmacology and Therapeutics) Kauppinen, Tiina (Pharmacology and Therapeutics) Gordon, Joe (Nursing) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2019 en_US


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