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A peel-able onion inspired multi-membrane chitosan hydrogel with reversible sol-gel transition, on-demanding dissolution for intestine-selective controlled release, shape memory, 3D printed E-skin biosensor and microchannel system

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dc.contributor.supervisor Xing, Malcolm (Mechanical Engineering) en_US
dc.contributor.author Singh, Gurankit
dc.date.accessioned 2018-12-04T20:05:31Z
dc.date.available 2018-12-04T20:05:31Z
dc.date.issued 2018 en_US
dc.date.submitted 2018-11-19T18:02:23Z en
dc.date.submitted 2018-12-04T18:30:30Z en
dc.date.submitted 2018-12-04T19:45:08Z en
dc.identifier.uri http://hdl.handle.net/1993/33585
dc.description.abstract There are numerous properties of biomaterials, existing in the nature which are still unknown to the scientific community. Different modifications to the biomaterials can unlock new properties of these materials. This leads to the development of whole new type of material which can be used as an alternative to the existing materials and contribute to wide range of new applications. Stimuli-responsive hydrogels are one of the best strategies for controlled drug delivery, tissue engineering and biosensing based applications. Here in we report, a novel pH-sensitive and biodegradable hydrogel systems based on the carboxymethyl chitosan (CMC). The mechanical property of CMC changes from acidic to basic medium. This property is the reversible sol-gel conversion (solution phase to gel phase) of CMC solution based on the pH changes, and it was used in this work to synthesize peel-able onion like multimembrane hydrogels for a controlled fluorescein drug delivery model to intestine in gastro-intestine systems. Dissolution rates of the hydrogels was altered by using different concentrations of CMC and different number of hydrogels layers. Furthermore, CMC was used as a novel 3D printable bioink for potential biomaterial-based applications. The resulting CMC 3D printed structures were further used as a real-time wireless biosensor and for designing microfluidic channels. The mechanical properties and characterization of the CMC were studied by using rheology tests, FT-IR and 1H NMR. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Chitosan, peel-able onion-like multi-membrane gel, shape memory, reversible sol-gel, 3D printing bioink, microfluidics, gastric-intestine controlled release en_US
dc.title A peel-able onion inspired multi-membrane chitosan hydrogel with reversible sol-gel transition, on-demanding dissolution for intestine-selective controlled release, shape memory, 3D printed E-skin biosensor and microchannel system en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Mechanical Engineering en_US
dc.contributor.examiningcommittee Zhong, Wen (Biosystems Engineering) Deng, Chuang (Mechanical Engineering) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2019 en_US


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