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Surface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Technique

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dc.contributor.author Li, Jiang
dc.contributor.author Lin, Francis
dc.contributor.author Li, Lingdong
dc.contributor.author Li, Jing
dc.contributor.author Liu, Song
dc.date.accessioned 2018-10-09T15:18:28Z
dc.date.available 2018-10-09T15:18:28Z
dc.date.issued 2012-05-08
dc.date.submitted 2018-10-05T21:28:38Z en
dc.identifier.citation Li, J.; Lin, F.; Li, L.; Li, J.; Liu, S.* Surface engineering of poly(ethylene terephthalate) for durable hemocompatibility via a surface interpenetrating network technique. Macromolecular Chemistry and Physics, 2012; 213(20): 2120–2129. en_US
dc.identifier.uri http://hdl.handle.net/1993/33530
dc.description.abstract Heparin was covalently bonded on chemically inert PET substrate using a surface modifi cation technique–surface interpenetrating network with the purpose of fabricating long-lasting biocompatible materials as vascular grafts. FTIR and XPS spectra confi rmed the successful heparinization of PET (PET-Hep). The density of surface-immobilized heparin as quantifi ed by a colorimetric method could reach 2.4 μ g cm − 2 (in the reported optimal range: 1.5–3.0 μ g cm − 2 ). The hemocompatibility of the heparin-immobilized PET was improved as evidenced by a platelet adhesion test: signifi cantly less platelet adhesion on PET-Hep (11.60%) than on untreated PET (48.91%). An MTT assay indicated PET-Hep was nontoxic to human dermal fi broblast cells. After an initial 5.24% loss of heparin from PETHep in the fi rst 14 h immersion in PBS buffer solution, no further leaching of heparin was found. en_US
dc.description.sponsorship the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (Grant no.:RGPIN/372048-2009) the Manitoba Health Research Council (MHRC) Establishment grant. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Surface Engineering of Poly(ethylene terephthalate) en_US
dc.subject Surface Interpenetrating Network en_US
dc.subject Durable Hemocompatibility en_US
dc.title Surface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Technique en_US
dc.type Article en_US
dc.identifier.doi 10.1002/macp.201200251


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