Home

Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery

Show simple item record

dc.contributor.author He, Wei
dc.contributor.author Gu, Xiaochen
dc.contributor.author Liu, Song
dc.date.accessioned 2018-10-09T15:14:41Z
dc.date.available 2018-10-09T15:14:41Z
dc.date.issued 2012-03-08
dc.date.submitted 2018-10-05T21:23:09Z en
dc.identifier.citation He, W.; Gu, X.; Liu, S.* Surfactant-free One-Step Synthesis of Dual-functional Polyurea Microcapsule: Contact Infection Control and Drug Delivery. Advanced Functional Materials, 2012; 22(19): 4023-31. en_US
dc.identifier.uri http://hdl.handle.net/1993/33529
dc.description.abstract Surface functionalized polyurea microcapsules (MCQ) are synthesized in one step. Dimethyl-dodecyl-(5-hydroxy-pentyl)-ammonium bromide (DAB), a hydroxyl-end-capped quaternary ammonium salt, is synthesized and adopted as a new surfmer for the synthesis of MCQ. It is confirmed by fluorescein adsorption that DAB is covalently bonded to MCQ. The so-formed MCQ possess dual-functionality: contact infection control and sustained drug delivery. Agar diffusion antimicrobial tests confirm successful inhibition of multidrug- resistant E. coli by MCQ alone instead of by leaching of free quaternary ammonium salts. Furthermore, few E. coli colonies survive on an agar plate coated with 3–4 layers of MCQ. Dissolution tests show a typical first-order release profile of courmarin-1, a model dye, from MCQ. en_US
dc.description.sponsorship the Manitoba Health Research Council Operating, and Establishment Grants the Dr. Paul H.T. Thorlakson Foundation the University of Manitoba Research Grant Program. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Polyurea Microcapsules en_US
dc.subject Surfactant-Free One-Step Synthesis of Microcapsules en_US
dc.subject Dual-Functional Microcapsules en_US
dc.subject infection control en_US
dc.title Surfactant-Free One-Step Synthesis of Dual-Functional Polyurea Microcapsules: Contact Infection Control and Drug Delivery en_US
dc.type Article en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi 10.1002/adfm.201200656


Files in this item

This item appears in the following Collection(s)

Show simple item record

View Statistics