Inflammatory pattern in HIV patients with Community acquired pneumonia and it's relationship with pulmonary dysfunction.

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dc.contributor.author Mao, Tony
dc.date.accessioned 2018-10-03T16:17:58Z
dc.date.available 2018-10-03T16:17:58Z
dc.date.issued 2018-08-23
dc.date.submitted 2018-10-03T16:17:58Z en
dc.identifier.citation AMA en_US
dc.identifier.uri http://hdl.handle.net/1993/33516
dc.description.abstract Prior studies have shown that HIV patients develop permanent pulmonary dysfunction following an episode of community acquired pneumonia (CAP). However, the mechanism causing pulmonary dysfunction remains an enigma. HIV patients experience chronic inflammation. We hypothesized that CAP infection worsens inflammation in HIV patients which leads to an accelerated decline in pulmonary function. A prospective cohort pilot study was performed, participants include patients hospitalized in Hospital Universitario San Vicente Fundación and Clínica SOMA, in Medellín, Colombia. Sixteen patients were eligible for the study, they were split into two groups: HIV and HIV+CAP. Plasma, sputum and pulmonary function test (PFT) measurements were retrieved within 48 hours of hospital admission and at one month follow-up. The concentrations of 13 molecules and PFT values were compared between the two cohorts. HIV+CAP group demonstrated a decline in pulmonary function compared to the HIV group, FVC%predicted and FEV1%predicted decreased while FEV1/FVC remained constant. APRIL, BAFF and TIMP-1 trended towards higher concentrations in the HIV+CAP group compared to the HIV group. These three molecules correlated negatively with FVC%predicted and FEV1%predicted, they have the potential to serve as biomarkers for predicting pulmonary dysfunction. Furthermore, the concentrations of BAFF, CCL3 and TIMP-1 were statistically significant between the two groups (=0.05). These molecules are involved in inflammation response in humans. We speculate that abnormal expression of these molecules may play a role in dysregulating inflammatory response, which leads to pulmonary dysfunction. These results need to be replicated with larger cohorts and longer follow-up time (to assess for permanent pulmonary dysfunction). en_US
dc.description.sponsorship H.T. Thorlakson Foundation Dean, College of Medicine Research Manitoba Manitoba Medical Service Foundation (MMSF) Vice-Dean, Research Rady FHS Health Sciences Centre Research Foundation Heart and Stroke Foundation en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject community acquired pneumonia (CAP) en_US
dc.subject HIV en_US
dc.subject pulmonary function test (PFT) en_US
dc.subject pulmonary dysfunction en_US
dc.title Inflammatory pattern in HIV patients with Community acquired pneumonia and it's relationship with pulmonary dysfunction. en_US
dc.type info:eu-repo/semantics/bachelorThesis
dc.type bachelor thesis en_US

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