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dc.contributor.supervisorAnderson, Judith (Human Anatomy and Cell Science)en
dc.contributor.authorHuebner, Kyla Danielle
dc.date.accessioned2007-04-26T19:01:49Z
dc.date.available2007-04-26T19:01:49Z
dc.date.issued2007-04-26T19:01:49Z
dc.identifier.urihttp://hdl.handle.net/1993/329
dc.description.abstractThe effects of the antifibrotic drug Halofuginone hydrobromide (Halo) on muscle function, regeneration and cardiorespiratory function were studied using mdx mice. It was hypothesized that Halo treatment would resolve pre-established fibrosis and prevent collagen deposits, improving muscle and cardio-respiratory function. Mice 8-9 mos were treated with saline or Halo for 5 (n = 4/group), 10 (n = 5/group) and 12 weeks (n = 4-5/group). Muscle strength and endurance, respiration and muscle susceptibility to damage were assessed. Tissues were collected from all mice. Additional mice were treated for 10 wks (3-4 wks n = 9-10/group; 8-9 mos n = 8-9/group) for echocardiography. Halo reduced fibrosis. As a consequence, there was muscle repair and damage was reduced. There were functional improvements and disease progression was slowed. There was resolution of pre-existing fibrosis and reduction of new collagen synthesis. This treatment could improve quality of life and lengthen the lifespan of DMD patients.en
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dc.format.extent2310116 bytes
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dc.format.mimetypeapplication/octet-stream
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypeapplication/octet-stream
dc.format.mimetypeapplication/pdf
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDystrophyen
dc.subjectFibrosisen
dc.titleCombating fibrosis in mdx mice with a novel antifibrosis drug - Halofuginoneen
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineHuman Anatomy and Cell Scienceen_US
dc.contributor.examiningcommitteeThliveris, James (Human Anatomy and Cell Science) Scott, Elliott (Oral Biology)en
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteMay 2007en


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