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dc.contributor.supervisorEck, Peter (Food and Human Nutritional Sciences) Jones, Peter (Food and Human nutritional Sciences)en_US
dc.contributor.authorShamloo, Maryam
dc.date.accessioned2018-03-19T18:26:07Z
dc.date.available2018-03-19T18:26:07Z
dc.date.issued2017-08-22en_US
dc.date.submitted2018-03-14T20:53:38Zen
dc.identifier.citationShamloo, M. et al. Effects of genotype and temperature on accumulation of plant secondary metabolites in Canadian and Australian wheat grown under controlled environments. 7, 9133, doi:10.1038/s41598-017-09681-5 (2017).en_US
dc.identifier.urihttp://hdl.handle.net/1993/32911
dc.description.abstractRegular daily intakes of whole grain products are associated with reduced risk of several diseases including type 2 diabetes. The health benefits of whole grains are linked to the existence of secondary bioactive metabolites including phenolic acids (PAs), flavonoids, and phytosterols. The production of these secondary metabolites in plants and the associated health properties is strongly dependent on the plant’s genetic and agro-climate environmental variations. Temperature as an abiotic factor has a powerful effect on a plant’s response to produce the secondary metabolites. Yet, how global warming influences wheat and other major crops’ secondary metabolite profiles and the associated health-promoting benefits remain unknown. The objective of this study was to investigate the genotypic and environmental factors that affect the production of wheat secondary metabolites and their associated health benefits. In the first phase of the present study, wheat varieties, representing different commercial classes, were grown at different geographical locations over two consecutive crop years. Genotypes and environment variations resulted in significant changes in wheat secondary metabolites’ levels and composition. Additionally, the impact of genotype, growth year and location variations on physiologic relevance was studied via investigating the ability of wheat’s phenolic acids to inhibit glucose uptake in a cell model of small intestinal transport. The degree of inhibition was defined by wheat genotype and growing environment conditions. In the second phase, we investigated if different growing temperatures could alter the accumulation of these secondary metabolites in different wheat varieties. Increased levels of phenolic acids and flavonoids were observed for wheat grains grown at higher temperatures. Extracts of wheat phenolics inhibited glucose accumulation in the CaCo-2 model of intestinal uptake, and this effect positively correlated with the phenolic contents and growth temperatures. The results offer a possible mechanism on how the addition of whole wheat products in the human diet improves postprandial glycemic responses through blunted glucose absorption.en_US
dc.language.isoengen_US
dc.publisherNature Scientific Reporten_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSecondary metabolites, Wheat, Global Warming, Environment and Genotypesen_US
dc.titleEffects of genotype and environment variation on wheat secondary metabolites and human health propertiesen_US
dc.typeinfo:eu-repo/semantics/doctoralThesis
dc.typedoctoral thesisen_US
dc.degree.disciplineFood and Nutritional Sciencesen_US
dc.contributor.examiningcommitteeArntfield, Susan (Food and Human Nutritional Sciences) House, James (Food and Human Nutritional Sciences) Kerem, Zohar (The Hebrew University of Jerusalem)en_US
dc.degree.levelDoctor of Philosophy (Ph.D.)en_US
dc.description.noteMay 2018en_US
local.subject.manitobayesen_US


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