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The impact of mean arterial pressure on functional outcome post-acute spinal cord injury: a systematic review of animal models and human clinical data

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dc.contributor.supervisor Berrington, Neil (Surgery) en_US
dc.contributor.author Sabit, Behzad
dc.date.accessioned 2017-09-13T17:33:04Z
dc.date.available 2017-09-13T17:33:04Z
dc.date.issued 2016 en_US
dc.identifier.citation “The Impact of Mean Arterial Pressure on Functional Outcome Post Trauma-Related Acute Spinal Cord Injury: A Scoping Systematic Review of the Human Literature” J Intensive Care Med. 2016 Oct 12 en_US
dc.identifier.citation “The Impact of Mean Arterial Pressure on Functional Outcome Post-Acute Spinal Cord Injury: A Scoping Systematic Review of Animal Models” J Neurotrauma. 2016 Oct 27. en_US
dc.identifier.uri http://hdl.handle.net/1993/32596
dc.description.abstract The occurrence of hypotension has been shown to be associated with worse outcomes after traumatic injury, including severe head injury. To our knowledge, a prospective controlled assessment of the effects of hypotension on acute spinal cord injury (ASCI) in humans has not been performed. Animal models of ASCI have been created in laboratory and data is extrapolated to the clinical setting, suggesting that hypotension contributes to secondary injury after ASCI by reducing spinal cord blood flow and perfusion.Given the lack of conclusive evidence on the topic, we set out to perform a comprehensive review of the pertinent evidence, first of the animal models on which the current guidelines are based, followed by a review of the human clinical data which is available. The goal was to assess the merit of the current guidelines and ascertain the correct target MAP immediately after ASCI as well as the duration for which this MAP must be targeted. en_US
dc.publisher Journal of intensive care medicine, Journal of neurotrauma en_US
dc.subject spinal cord injury en_US
dc.subject mean arterial pressure en_US
dc.subject directed therapy en_US
dc.title The impact of mean arterial pressure on functional outcome post-acute spinal cord injury: a systematic review of animal models and human clinical data en_US
dc.degree.discipline Surgery en_US
dc.contributor.examiningcommittee Srinathan, Sadeesh (Surgery) Kaufmann, Anthony (Surgery) Schmidt, Brian (Internal Medicine) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2017 en_US


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