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Activation of descending vestibulospinal pathways perturbs the pattern of ongoing locomotion demonstrated in the in vitro neonatal rat brainstem-spinal cord preparation

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dc.contributor.supervisor Cowley, Kristine (Physiology and Pathophysiology) en_US
dc.contributor.author Morfín-Cruz, Ramiro
dc.date.accessioned 2017-09-05T21:38:48Z
dc.date.available 2017-09-05T21:38:48Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/1993/32430
dc.description.abstract Stance, stepping and balance; all individual phenomena, equally important to achieve the basic function of walking. Since the last century efforts have been made to better understand the physiology underlying these fundamental yet extremely complex neuronal functions. Resetting locomotor activity was obtained by stimulating vestibular afferents in an in vitro neonatal rat spinal cord preparation by delivering electrical impulses with diverse parameters in the presence of drug-induced rhythmic locomotor activity. Inputs from other supraspinal and peripheral neural structures were limited by selective lesioning, such that only ipsilateral descending ventral pathways remained intact. We demonstrated the relevance and influence of vestibular stimulation as an early termination of a locomotor flexor phase and prolongation of the extensor component, recorded bilaterally at the lumbar level from the nerve roots corresponding to hindlimb flexors and extensors. These effects included changes in amplitude and timing of the rhythmic discharge; this thesis focuses on description of the changes in timing of ongoing locomotor activity that occurs due to stimulation of descending vestibulospinal input. The distribution of the lumbar commissural interneurons mediating these responses remains to be characterized, although, the findings of this thesis suggest that their network array could be redundantly distributed among the rostrocaudal extent of the lumbar cord. en_US
dc.subject Motor control en_US
dc.subject Spinal cord en_US
dc.subject Balance en_US
dc.title Activation of descending vestibulospinal pathways perturbs the pattern of ongoing locomotion demonstrated in the in vitro neonatal rat brainstem-spinal cord preparation en_US
dc.degree.discipline Physiology and Pathophysiology en_US
dc.contributor.examiningcommittee Schmidt, Brian (Internal Medicine) MacNeil, Brian (Physical Therapy) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2017 en_US


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