c-Myc- driven nuclear repositioning of chromosome 11 in mouse plasmacytomas and its clinical significance
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Date
2016
Authors
Sunpaweravong, Patrapim
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Abstract
Overall, this study enhances our understanding of the role of c-Myc activation in chromosome 11 repositioning in mouse PreB v-abl/myc cells and a possible interaction between telomeres, TRF2, and lamin A/C underlying this phenomenon. Additionally, the importance of human 17q25.3 is confirmed as a potential region involved in NSCLC tumorigenesis. A utilizationof the 3D telomeric organization profiles is demonstrated a tendency to categorize NSCLC patients into different prognostic subgroups, underscoring a potential future value of its clinical application.
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Keywords
c-Myc, Repositioning, Mouse chromosome 11, Plasmacytomas, Non-small cell lung cancer, Three-dimensional, Telomeres, Nuclear matrix, TRF2, Lamin A/C