Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method

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Date
1992-1-1
Authors
Chagla, Abdul H
Hii, John H
Hoban, Daryl J
Simor, Andrew E
Ferro, Santiago
Witwicki, Evelyn
Poon, Ruby
Low, Donald E
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Abstract
The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.
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Abdul H Chagla, John H Hii, Daryl J Hoban, et al., “Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method,” Canadian Journal of Infectious Diseases, vol. 3, no. 5, pp. 231-234, 1992. doi:10.1155/1992/260839