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Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method

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dc.contributor.author Chagla, Abdul H
dc.contributor.author Hii, John H
dc.contributor.author Hoban, Daryl J
dc.contributor.author Simor, Andrew E
dc.contributor.author Ferro, Santiago
dc.contributor.author Witwicki, Evelyn
dc.contributor.author Poon, Ruby
dc.contributor.author Low, Donald E
dc.date.accessioned 2016-06-09T19:14:42Z
dc.date.available 2016-06-09T19:14:42Z
dc.date.issued 1992-1-1
dc.identifier.citation Abdul H Chagla, John H Hii, Daryl J Hoban, et al., “Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method,” Canadian Journal of Infectious Diseases, vol. 3, no. 5, pp. 231-234, 1992. doi:10.1155/1992/260839
dc.identifier.uri http://dx.doi.org/10.1155/1992/260839
dc.identifier.uri http://hdl.handle.net/1993/31488
dc.description.abstract The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory concentration [MIC] 3.2 μg/mL) but was inactive against other Candida species. When testing the susceptibility of cilofungin, 5-flucytosine and amphotericin B at the two centres, approximately 90% of the Candida strains had MICs differing by fourfold or less. However, when testing susceptibility of ketoconazole, only 51% of the Candida strains had MIC differences fourfold or less. MIC susceptibility testing with cilofungin, 5-flucytosine and amphotericin B in saam-f medium is reproducible.
dc.title Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method
dc.type Journal Article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.date.updated 2016-06-07T07:05:24Z


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