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Canadian Prediction Equations of Spirometric Lung Function for Caucasian Adults 20 to 90 Years of Age: Results from the Canadian Obstructive Lung Disease (COLD) Study and the Lung Health Canadian Environment (LHCE) Study

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dc.contributor.author Tan, WC
dc.contributor.author Bourbeau, J
dc.contributor.author Hernandez, P
dc.contributor.author Chapman, K
dc.contributor.author Cowie, R
dc.contributor.author FitzGerald, MJ
dc.contributor.author Aaron, S
dc.contributor.author Marciniuk, DD
dc.contributor.author Maltais, F
dc.contributor.author O’Donnell, DE
dc.contributor.author Goldstein, R
dc.contributor.author Sin, D
dc.contributor.author Chan-Yeung, M
dc.contributor.author Manfreda, J
dc.contributor.author Anthonisen, NR
dc.contributor.author Tate, RB
dc.contributor.author Sears, MR
dc.contributor.author Siersted, HC
dc.contributor.author Becklake, MR
dc.contributor.author Ernst, P
dc.contributor.author Bowie, DM
dc.contributor.author Sweet, L
dc.contributor.author Van Til, L
dc.date.accessioned 2016-06-07T20:27:46Z
dc.date.available 2016-06-07T20:27:46Z
dc.date.issued 2011-1-1
dc.identifier.citation WC Tan, J Bourbeau, P Hernandez, et al., “Canadian Prediction Equations of Spirometric Lung Function for Caucasian Adults 20 to 90 Years of Age: Results from the Canadian Obstructive Lung Disease (COLD) Study and the Lung Health Canadian Environment (LHCE) Study,” Canadian Respiratory Journal, vol. 18, no. 6, pp. 321-326, 2011. doi:10.1155/2011/540396
dc.identifier.uri http://dx.doi.org/10.1155/2011/540396
dc.identifier.uri http://hdl.handle.net/1993/31362
dc.description.abstract BACKGROUND: Currently, no reference or normative values for spirometry based on a randomly selected Canadian population exist.OBJECTIVE: The aim of the present analysis was to construct spirometric reference values for Canadian adults 20 to 90 years of age by combining data collected from healthy lifelong nonsmokers in two population-based studies.METHOD: Both studies similarly used random population sampling, conducted using validated epidemiological protocols in the Canadian Obstructive Lung Disease study, and the Lung Health Canadian Environment study. Spirometric lung function data were available from 3042 subjects in the COLD study, which was completed in 2009, and from 2571 subjects in the LHCE study completed in 1995. A total of 844 subjects 40 to 90 years of age, and 812 subjects 20 to 44 years of age, were identified as healthy, asymptomatic, lifelong nonsmokers, and provided normative reference values for spirometry. Multiple regression models were constructed separately for Caucasian men and women for the following spirometric parameters: forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio, with covariates of height, sex and age. Comparison with published regression equations showed that the best agreement was obtained from data derived from random populations.RESULTS: The best-fitting regression models for healthy, never-smoking, asymptomatic European-Canadian men and women 20 to 90 years of age were constructed. When age- and height-corrected FEV1, FVC and FEV1/FVC ratio were compared with other spirometry reference studies, mean values were similar, with the closest being derived from population-based studies.CONCLUSION: These spirometry reference equations, derived from randomly selected population-based cohorts with stringently monitored lung function measurements, provide data currently lacking in Canada.
dc.title Canadian Prediction Equations of Spirometric Lung Function for Caucasian Adults 20 to 90 Years of Age: Results from the Canadian Obstructive Lung Disease (COLD) Study and the Lung Health Canadian Environment (LHCE) Study
dc.type Journal Article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.date.updated 2016-06-07T06:55:18Z


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