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Characterize the anti-HIV-1 activity of a kinase inhibitor kenpaullone and the HIV-1 integrase association with DIC1 and DYNLT1

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dc.contributor.supervisor Yao, Xiaojian (Medical Microbiology) en_US
dc.contributor.author Chen, Bihe
dc.date.accessioned 2016-04-20T23:14:52Z
dc.date.available 2016-04-20T23:14:52Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/1993/31253
dc.description.abstract Advances in the antiretroviral therapy (ART) have dramatically reduced the death rate from human immunodeficiency virus type 1 (HIV-1) induced acquired immune deficiency syndrome (AIDS). However, it is still necessary to develop anti-HIV-1 new drugs. In this study, two projects were conducted and may contribute to the new drug development. The first project is focused on characterizing the anti-HIV activity of a kinase inhibitor Kenpaullone (Ken). We found a cyclin dependent kinase (CDK) and glycogen synthase kinase-3β (GSK-3β) inhibitor named Ken can significantly inhibit HIV-1 replication. Mechanistic analysis by RT-PCR revealed that Ken inhibited HIV-1 replication by disrupting transcription possibly through CDK-dependent pathways. The second project is focused on understanding the association between HIV-1 integrase (IN) and dynein components. Our investigation indicated that HIV-1 IN is associated with DIC1 and DYNLT1. Further investigation this IN/dynein component association may help to reveal new anti-HIV targets. en_US
dc.subject HIV-1 en_US
dc.subject Kinase en_US
dc.subject Kenpaullone en_US
dc.subject Integrase en_US
dc.subject Dynein en_US
dc.title Characterize the anti-HIV-1 activity of a kinase inhibitor kenpaullone and the HIV-1 integrase association with DIC1 and DYNLT1 en_US
dc.degree.discipline Medical Microbiology en_US
dc.contributor.examiningcommittee McClarty, Grant (Medical Microbiology) Mizuno, Tooru (Physiology and Pathophysiology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note May 2016 en_US


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