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A layer of hydrogel on PET dressings for low wound adherence and as a reservoir for new dendrimer based biocides for burn wound infection control

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dc.contributor.supervisor Liu, Song (Biosystems Engineering) en_US
dc.contributor.author Asghari, Sogol
dc.date.accessioned 2015-12-23T14:40:30Z
dc.date.available 2015-12-23T14:40:30Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/1993/30985
dc.description.abstract Bacterial infection in burn wounds can jeopardize healing and can even lead to a patient’s death. Recently using a topical wound dressing with antimicrobial ability has been increasing. An ideal dressing for a burn wound is required to be antimicrobial, pain free and able to control the wound moisture to facilitate healing. In this research, a UV-radiation grafting method for depositing polyacrylamide (PAM) layer was used to improve the non-adherence properties of two commercially available silver based wound dressings. The dressing adherence, evaluated via an in vitro gelatine model, dramatically decreases after the deposition of PAM. This deposition did not negatively affect the antibacterial ability and cytotoxicity of the dressings. Furthermore, a poly(amidoamine) dendrimer based biocide was incorporated into PET dressings coated with poly(acrylic acid-co-acrylamide ) hydrogel. The resulting dressing was able to release a therapeutic dose of the antimicrobial agent in a sustained manner. en_US
dc.subject Low wound adherence en_US
dc.subject Silver dressing en_US
dc.subject Hydrogel en_US
dc.subject Acrylamide en_US
dc.subject Wound infection control en_US
dc.subject Dendrimer based biocide en_US
dc.title A layer of hydrogel on PET dressings for low wound adherence and as a reservoir for new dendrimer based biocides for burn wound infection control en_US
dc.degree.discipline Biosystems Engineering en_US
dc.contributor.examiningcommittee Logsetty,Sarvesh (Surgery) Gu, Xiaochen (College of Pharmacy) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2016 en_US


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