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dc.contributor.supervisor Fowke, Keith (Medical Microbiology) en_US
dc.contributor.author Stalker, Andrew
dc.date.accessioned 2015-09-01T20:49:09Z
dc.date.available 2015-09-01T20:49:09Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/1993/30708
dc.description.abstract LAG-3 is an immune inhibitory marker. These immune inhibitory markers function to reduce the capability of immune cells to elicit a proper immune response and to help maintain tolerance. During an acute infection, these markers assist in controlling the immune system, however, during a chronic infection these markers prevent the immune response from persisting to effectively fight the disease. Contrary to other immune inhibitory markers, LAG-3 is not highly expressed on T cells during chronic viral infections, such as HIV. The majority of information available on LAG-3 has been gained from murine models and cell lines. This thesis uses primary human T cells in order to observe rapid expression of surface LAG-3 from a pre-formed intracellular store and cleavage of these surface molecules into soluble variants by matrix metalloprotease cleavage. LAG-3 and sLAG-3 expression is compared with CD69 and cytokine expression to help understand the early immune response. en_US
dc.subject LAG-3 en_US
dc.subject Immunology en_US
dc.subject T cells en_US
dc.subject CD4 en_US
dc.subject CD3 en_US
dc.subject HIV en_US
dc.title Understanding the rapid expression of lymphocyte activation gene 3 (LAG-3) on healthy human T cells en_US
dc.degree.discipline Medical Microbiology en_US
dc.contributor.examiningcommittee Yang, Xi (Medical Microbiology) Ho, Emmanuel (Pharmacy) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2015 en_US


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