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dc.contributor.supervisor Friel, James (Human Nutritional Sciences) en_US
dc.contributor.author Qasem, Wafaa
dc.date.accessioned 2015-07-29T15:04:35Z
dc.date.available 2015-07-29T15:04:35Z
dc.date.issued 2015-05-05 en_US
dc.identifier.citation Qasem W, Friel J (2015) The Recommended First Complementary Foods: A Review of the Literature. J Pediatr Neonatal Care 2(2): 00069. DOI: 10.15406/jpnc.2015.02.00069 en_US
dc.identifier.uri http://hdl.handle.net/1993/30638
dc.description.abstract Health Canada recommends exclusive breastfeeding (EBF) until 6 months followed by introducing iron-rich complementary foods (CFs) such as iron-fortified cereal and meat to prevent iron deficiency (ID). There is a concern that consumption of CFs with high iron dose may predispose infants to inflammation through reactive oxygen species (ROS) generation in their intestinal tract. The nutrient intake from these recommended first CFs had not been assessed in terms of meeting the daily requirements. Therefore the aim of this study was to assess if the recommended CFs are safe from a free radical and inflammatory perspective and to assess these CFs in relation to socio-demographic characteristics, feeding patterns, nutrient intake, iron status and growth. Eighty-seven EBF infants were randomly assigned to receive one of the following: iron-fortified cereal (Cer), iron-fortified cereal with fruit (Cer+Fr), meat (M). Urine and stool samples were collected before and after introduction of CFs to assess the following markers: urinary F2-Isoprostanes, fecal ROS, fecal iron and fecal calprotectin. Blood was collected from 18 infants to measure iron parameters. Socio-demographic characteristics and feeding patterns were obtained using questionnaires. Nutrient intake was collected using 3-day dietary records. There are maternal factors that were associated with selected feeding patterns. Nutrient intake was only adequate when provided by both breast milk and CFs. Plasma ferritin decreased over time in all groups (p = 0.04). Infants in M group had lower fecal iron than infants in Cer and Cer+Fr groups (p < 0.001, p = 0.014, respectively). An increase in fecal ROS formation (p < 0.002) after the introduction of CFs was observed. There are maternal socio-demographic factors such as lower parity and lower BMI that need to be targeted in the future to optimize feeding time, type and frequency. Infants with EBF may be at risk of developing ID despite the provision of iron-rich CFs. Untargeted iron fortification may result in untoward effects including ROS generation in the infant’s intestinal tract. In future, if these findings are further confirmed in EBF and formula-fed infants, reconsidering the strategies of iron fortifications to both meet infants’ requirements and minimizing oxidative stress maybe warranted. en_US
dc.publisher MedCrave group en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Complementary feeding en_US
dc.subject Full term infant en_US
dc.subject Exclusive breastfeeding en_US
dc.subject Iron status en_US
dc.subject Oxidative stress en_US
dc.title Assessment of complementary feeding of Canadian infants en_US
dc.type info:eu-repo/semantics/doctoralThesis
dc.type doctoral thesis en_US
dc.degree.discipline Human Nutritional Sciences en_US
dc.contributor.examiningcommittee House, James (Human Nutritional Sciences) Beta, Trust (Food Science) Keijzer, Richard (Surgery) Field, Catherine (University of Alberta) en_US
dc.degree.level Doctor of Philosophy (Ph.D.) en_US
dc.description.note October 2015 en_US


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