Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients
Loading...
Date
2012-10-17
Authors
Huyen, V. T. T.
Phan, D. V.
Thang, P.
Ky, P. T.
Hoa, N. K.
Ostenson, C. G.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aims. To investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum (GP) together with sulfonylurea (SU) in 25 drug-naïve type 2 diabetic patients.
Methods. After 4-week treatment with gliclazide (SU), 30 mg daily, all patients were randomly assigned into 2 groups to add on GP extract or placebo extract, 6 g daily, during eight weeks.
Results. After 4-week SU treatment, fasting plasma glucose (FPG) and Hb decreased significantly (). FPG was further reduced after add-on therapy with 2.9 ± 1.7 and 0.9 ± 0.6 mmol/L in the GP and placebo groups, respectively (). Therapy with GP extract also reduced 30- and 120-minute oral glucose tolerance test postload values. Hb levels decreased approximately 2% units in the GP group compared to 0.7% unit in the placebo group ().
Conclusion. GP extract in addition to SU offers an alternative to addition of other oral medication to treat type 2 diabetic patients.
Description
Keywords
Citation
V. T. T. Huyen, D. V. Phan, P. Thang, P. T. Ky, N. K. Hoa, and C. G. Ostenson, “Antidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic Patients,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 452313, 7 pages, 2012. doi:10.1155/2012/452313