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dc.contributor.authorBowen, Joslin M.
dc.contributor.authorPerry, Anamarija M.
dc.contributor.authorQuist, Erin
dc.contributor.authorAkhtari, Mojtaba
dc.date.accessioned2015-05-14T15:31:56Z
dc.date.available2015-05-14T15:31:56Z
dc.date.issued2015-4-16
dc.identifier.citationJoslin M. Bowen, Anamarija M. Perry, Erin Quist, and Mojtaba Akhtari, “Extramedullary Hematopoiesis in a Sentinel Lymph Node as an Early Sign of Chronic Myelomonocytic Leukemia,” Case Reports in Pathology, vol. 2015, Article ID 594970, 4 pages, 2015. doi:10.1155/2015/594970
dc.identifier.urihttp://dx.doi.org/10.1155/2015/594970
dc.identifier.urihttp://hdl.handle.net/1993/30445
dc.description.abstractChronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy with features of both a myeloproliferative neoplasm and a myelodysplastic syndrome. Even though extramedullary leukemic infiltration is common in CMML patients, lymph node involvement has rarely been reported in the literature. We present an unusual case of a 72-year-old female who was found to have extramedullary hematopoiesis (EMH) in a sentinel lymph node that was excised during mastectomy for lobular breast carcinoma. One year later bone marrow biopsy was performed due to persistent anemia, thrombocytopenia, and monocytosis and the patient was diagnosed with CMML. Our case illustrates the importance of recognizing EMH in a lymph node during routine histological examination, especially in adults. Proliferation of bone marrow elements in a lymph node, in a patient with no known hematologic disorder, should trigger immediate bone marrow evaluation, as this could be the first clue in diagnosing underlying bone marrow disorder.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleExtramedullary Hematopoiesis in a Sentinel Lymph Node as an Early Sign of Chronic Myelomonocytic Leukemia
dc.typeJournal Article
dc.typeinfo:eu-repo/semantics/article
dc.language.rfc3066en
dc.description.versionPeer Reviewed
dc.rights.holderCopyright © 2015 Joslin M. Bowen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.date.updated2015-04-18T07:01:27Z


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