Search
Now showing items 1-10 of 216
Targeting the Mevalonate Cascade as a New Therapeutic Approach in Heart Disease, Cancer and Pulmonary Disease
(Elsevier, 2014-02-26)
The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) ...
Geographic and facility-level variation in the use of peritoneal dialysis in Canada: a cohort study
(CMA, 2014)
Background Peritoneal dialysis is associated with similar survival and similar improvement in quality of life and is less costly compared with in-centre hemodialysis. We examined facility and geographic variation in the ...
Single nucleotide polymorphisms in SLC22A23 are associated with ulcerative colitis in a Canadian Caucasian cohort
(American Journal of Clinical Nutrition, 2014)
Abstract
BACKGROUND:
SLC22A23 is an orphan gene in the SLC22 family of organic membrane transporters, and its single-nucleotide polymorphism rs17309827-T was recently nominally associated with intestinal inflammation in ...
Advances in the indirect, descriptive, and experimental approaches to the functional analysis of problem behavior
(Psicothema, 2014)
BACKGROUND:
Experimental functional analysis is an assessment methodology to identify the environmental factors that maintain problem behavior in individuals with developmental disabilities and in other populations. ...
Long-term benefits of full-day kindergarten: a longitudinal population-based study
(Taylor & Francis, 2014-06)
In the first longitudinal, population-based study of full-day kindergarten (FDK) outcomes beyond primary school in Canada, we used linked administrative data to follow 15 kindergarten cohorts (n ranging from 112 to 736) ...
What are adults with IBD eating? A closer look at the dietary habits of a population-based Canadian IBD cohort
(Journal of Parenteral and Enteral Nutrition, 2014-09-04)
Background: A comprehensive study of what individuals with inflammatory bowel disease (IBD) are eating that encompasses food avoidance, dietary sugar consumption, and a comparison with the non-IBD Canadian population has ...
Trends in utilization of diagnostic and therapeutic ERCP and cholecystectomy over the past 25 years: a population-based study.
(Gastroentestinal Endoscopy, 2014-04)
Abstract
BACKGROUND:
Comprehensive, population-based data on ERCP use over the last 30 years in North America are lacking.
OBJECTIVE:
To establish crude and age-adjusted population-based rates of ERCP, evaluate for ...
Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn’s disease
(American Journal of Clinical Nutrition, 2014)
Abstract
BACKGROUND:
Crohn disease (CD) and ulcerative colitis (UC) are 2 common inflammatory bowel diseases (IBDs) associated with intestinal inflammation and tissue damage. Oxidative stress is suggested to play a major ...
The primary importance of corporate social responsibility and ethicality in corporation reputation: an empirical study
(Business and Society Review, 2014-03-03)
We examine three assumptions commonly held in the corporate reputation literature: i) reputation ratings of owners and investors are generally representative of all stakeholders; ii) stakeholders will generally provide a ...
