• Libraries
    • Log in to:
    View Item 
    •   MSpace Home
    • Faculty of Graduate Studies (Electronic Theses and Practica)
    • FGS - Electronic Theses and Practica
    • View Item
    •   MSpace Home
    • Faculty of Graduate Studies (Electronic Theses and Practica)
    • FGS - Electronic Theses and Practica
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The effects of the deletion of VDAC on the physical properties and proteome of the mitochondrial outer membrane in Neurospora crassa

    Thumbnail
    View/Open
    Motnenko_Anna.pdf (2.650Mb)
    Date
    2014-08-21
    Author
    Motnenko, Anna
    Metadata
    Show full item record
    Abstract
    Mitochondria are essential organelles in the cell. They are enveloped by a two membrane system, an inner and outer membrane. Residing in the outer membrane is the voltage-dependant anion-selective channel (VDAC) which is in very high abundance in the outer membrane. Previously, when VDAC was deleted in N. crassa the mitochondria developed unusual morphology and the fungus became temperature sensitive. This was suspected to be caused by alterations in the membrane architecture. It was found that deletion of VDAC causes a reduction in mitochondrial outer membrane fluidity leading to a fragile outer membrane. In the current study it was also found that loss of VDAC significantly impacts the mitochondrial proteome. These results taken together suggest that VDAC is not only a channel for traversing the outer membrane but appears to be important for the structural integrity of the mitochondria.
    URI
    http://hdl.handle.net/1993/23838
    Collections
    • FGS - Electronic Theses and Practica [25494]

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of MSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV