Proactive immunity and vaccination against cutaneous leishmaniasis
Loading...
Date
2012-05-29
Authors
Uzonna, Jude
Okwor, Ifeoma
Mou, Zhirong
Dong, Liu
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers
Abstract
Although a great deal of knowledge has been gained from studies on the immunobiology of leishmaniasis, there is still no universally acceptable, safe, and effective vaccine against the disease. This strongly suggests that we still do not completely understand the factors that control and/or regulate the development and sustenance of anti-Leishmania immunity,particularly those associated with secondary (memory)immunity. Such an understanding is critically important for designing safe, effective, and universally acceptable vaccine against the disease. Here we review the literature on the correlate of protective anti-
Leishmania immunity and vaccination strategies against leishmaniasis with a bias
emphasis on experimental cutaneous leishmaniasi
Description
Keywords
Cutaneous leishmaniasis, Innate immunity, Adaptive immunity, Infection-induced resistance, Vaccine, Vaccination
Citation
Uzonna, J., Okwor, I., Mou, Z., Liu, D. Protective immunity and vaccination against cutaneous leishmaniasis. (2012) Front. Immun. 3, 1-13