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Thyroid development in larval lake sturgeon (Acipenser fulvescens) and the potential thyroid disruption associated with exposure to the organophosphate pesticide chlorpyrifos

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dc.contributor.supervisor Anderson, W. Gary (Biological Sciences) Palace, Vince (Biological Sciences) en_US
dc.contributor.author Burnett, Duncan
dc.date.accessioned 2014-04-23T20:59:17Z
dc.date.available 2014-04-23T20:59:17Z
dc.date.issued 2014-04-23
dc.identifier.uri http://hdl.handle.net/1993/23554
dc.description.abstract The thyroid hormone system plays a major role in larval development, growth, and metabolism in fish. Therefore, any anthropogenic alteration in thyroid function could have dramatic effects on individual fitness. In this study Lake Sturgeon, Acipenser fulvescens, larvae were exposed to a commercially used organophosphate pesticide, chlorpyrifos (0, 5, 500 and 2000ng/L), from hatch until the onset of exogenous feeding (~12 days at 14C). The presence of thyroid follicles was first observed at 6 days post hatch (dph). Molecular expression of thyroid receptor α (TRα) increased from 3 to 12dph and then decreased from 12 to 21dph. TRα expression was also significantly higher in brain, liver and muscle at 67dph when compared to TRβ. Of the circulating hormones only free-T3 was consistently measured in larval homogenates from all development time-points sampled. Exposure to chlorpyrifos had no effect on growth or thyroid follicle morphology during the course of the experiment. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject thyroid en_US
dc.subject development en_US
dc.subject larvae en_US
dc.subject sturgeon en_US
dc.subject chlorpyrifos en_US
dc.title Thyroid development in larval lake sturgeon (Acipenser fulvescens) and the potential thyroid disruption associated with exposure to the organophosphate pesticide chlorpyrifos en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Biological Sciences en_US
dc.contributor.examiningcommittee Treberg, Jason (Biological Sciences) Hanson, Mark (Environment and Geography) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note May 2014 en_US


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