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Cardiovascular magnetic resonance in pregnancy: Insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study

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dc.contributor.author Ducas, Robin A
dc.contributor.author Elliott, Jason E
dc.contributor.author Melnyk, Steven F
dc.contributor.author Premecz, Sheena
dc.contributor.author daSilva, Megan
dc.contributor.author Cleverley, Kelby
dc.contributor.author Wtorek, Piotr
dc.contributor.author Mackenzie, G S
dc.contributor.author Helewa, Michael E
dc.contributor.author Jassal, Davinder S
dc.date.accessioned 2014-01-07T00:06:49Z
dc.date.available 2014-01-07T00:06:49Z
dc.date.issued 2014-01-03
dc.identifier.citation Journal of Cardiovascular Magnetic Resonance. 2014 Jan 03;16(1):1
dc.identifier.uri http://hdl.handle.net/1993/23132
dc.description.abstract Abstract Background Cardiovascular disease in pregnancy is the leading cause of maternal mortality in North America. Although transthoracic echocardiography (TTE) is the most widely used imaging modality for the assessment of cardiovascular function during pregnancy, little is known on the role of cardiovascular magnetic resonance (CMR). The objective of the Cardiac Hemodynamic Imaging and Remodeling in Pregnancy (CHIRP) study was to compare TTE and CMR in the non-invasive assessment of maternal cardiac remodeling during the peripartum period. Methods Between 2010–2012, healthy pregnant women aged 18 to 35 years were prospectively enrolled. All women underwent TTE and CMR during the third trimester and at least 3 months postpartum (surrogate for non-pregnant state). Results The study population included a total of 34 women (mean age 29 ± 3 years). During the third trimester, TTE and CMR demonstrated an increase in left ventricular end-diastolic volume from 95 ± 11 mL to 115 ± 14 mL and 98 ± 6 mL to 125 ± 5 mL, respectively (p < 0.05). By TTE and CMR, there was also an increase in left ventricular (LV) mass during pregnancy from 111 ± 10 g to 163 ± 11 g and 121 ± 5 g to 179 ± 5 g, respectively (p < 0.05). Although there was good correlation between both imaging modalities for LV mass, stroke volume, and cardiac output, the values were consistently underestimated by TTE. Conclusion This CMR study provides reference values for cardiac indices during normal pregnancy and the postpartum state.
dc.title Cardiovascular magnetic resonance in pregnancy: Insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study
dc.type Journal Article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Robin A Ducas et al.; licensee BioMed Central Ltd.
dc.date.updated 2014-01-07T00:06:49Z
dc.identifier.doi http://dx.doi.org/10.1186/1532-429X-16-1


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