Natural killer cell function in chronic HCV infection
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Date
2013-08-21
Authors
Collister, Mark
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Abstract
NK cells control viral replication through cytotoxicity and IFNγ production. These functions were assessed in chronic HCV infected patients undergoing treatment. Aboriginals have genetic polymorphisms that may enhance NK cell function suggesting more effective clearance of chronic HCV than Caucasians.
NK cell function was similar at baseline between ethnicities. At 3 months of treatment, Caucasian had higher NK killing potential compared to Aboriginal patients. This had no effect on treatment outcomes. NK cell cytotoxicity negatively correlated with viral loads while NK IFNγ production, particularly within the CD56bright subset, positively correlated with viral load suggesting that viral loads control NK cells function through an unknown mechanism. NK cell killing reflect fibrosis, but not liver damage measured by liver enzymes. IFNγ production,by NK cells does not reflect fibrosis nor liver enzymes levels. Lastly, NK cell function does not associate with therapeutic outcomes of chronic HCV infection suggesting that they do not directly play a role in therapeutic clearance of HCV.
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Keywords
NK, HCV, Cytotoxicity, IFNγ