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dc.contributor.supervisor Rempel, Julia (Immunology) en_US
dc.contributor.author Collister, Mark
dc.date.accessioned 2013-08-21T14:29:12Z
dc.date.available 2013-08-21T14:29:12Z
dc.date.issued 2013-08-21
dc.identifier.uri http://hdl.handle.net/1993/22047
dc.description.abstract NK cells control viral replication through cytotoxicity and IFNγ production. These functions were assessed in chronic HCV infected patients undergoing treatment. Aboriginals have genetic polymorphisms that may enhance NK cell function suggesting more effective clearance of chronic HCV than Caucasians. NK cell function was similar at baseline between ethnicities. At 3 months of treatment, Caucasian had higher NK killing potential compared to Aboriginal patients. This had no effect on treatment outcomes. NK cell cytotoxicity negatively correlated with viral loads while NK IFNγ production, particularly within the CD56bright subset, positively correlated with viral load suggesting that viral loads control NK cells function through an unknown mechanism. NK cell killing reflect fibrosis, but not liver damage measured by liver enzymes. IFNγ production,by NK cells does not reflect fibrosis nor liver enzymes levels. Lastly, NK cell function does not associate with therapeutic outcomes of chronic HCV infection suggesting that they do not directly play a role in therapeutic clearance of HCV. en_US
dc.subject NK en_US
dc.subject HCV en_US
dc.subject Cytotoxicity en_US
dc.subject IFNγ en_US
dc.title Natural killer cell function in chronic HCV infection en_US
dc.degree.discipline Immunology en_US
dc.contributor.examiningcommittee Kung, Sam (Immunology) Carpenter, Michael (Medical Microbiology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2013 en_US


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