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dc.contributor.author Lee, Beverley en_US
dc.date.accessioned 2007-05-22T15:12:00Z
dc.date.available 2007-05-22T15:12:00Z
dc.date.issued 2000-12-01T00:00:00Z en_US
dc.identifier.uri http://hdl.handle.net/1993/1985
dc.description.abstract The mouse submaxillary gland protein (mSMGP) gene is highly expressed in the submandibular and lacrimal glands of the adult mouse. As a first step in elucidating the role of the mSMGP in the submandibular gland, gene expression in the developing mouse was examined. Using reverse transcriptase polymerase chain reaction (RT-PCR), Southern and Northern blot analyses, mSMGP gene expression in the prenatal submandibular gland was det cted as early as embryonic day 14 (E14), the approximate time at which submandibular gland development begins. By 'in situ' hybridization studies of the embryonic gland, mSMGP gene expression was localized to the acinar cells, the major secretory cells of the submandibular gland. The early and continued expression of the mSMGP gene in the embryo suggests that the mSMGP may be integral during submandibular gland development in the mouse. Sequence analysis of the mSMGP in our laboratory has revealed the presence of a signal peptide, suggesting that the mSMGP is a secreted protein. (Abstract shortened by UMI.) en_US
dc.format.extent 8083899 bytes
dc.format.extent 184 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language en en_US
dc.language.iso en_US
dc.title Developmental and functional analysis of the mouse submaxillary gland protein (mSMGP) en_US
dc.degree.discipline Pathology en_US
dc.degree.level Master of Science (M.Sc.) en_US


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