Show simple item record De Haney, Suzanne en_US 2007-05-18T20:03:27Z 2007-05-18T20:03:27Z 2000-12-01T00:00:00Z en_US
dc.description.abstract 'Introduction'. Tizanidine, an (_2-noradrenergic/imidazoline agonist, and baclofen, a GABAb agonist, have been shown to have both antinociceptive and myorelaxant effects. In this study, the relative effect of tizanidine and baclofen on motor performance was tested at comparable analgesic dosages in rats. 'Methods'. Analgesia was measured using the tail-flick test and an analgesic index was calculated based on the cumulative increase in tail-flick latency. Motor performance was measured from kinematic analysis of swimming and a performance index was calculated based on the cumulative decrement in swim speed. Drugs, tizanidine and baclofen, were administered intraperitoneally following three baseline measurements at twenty minute intervals and subsequently monitored at regular twenty minute intervals for a period of two hours. Three comparable dosages were identified based on analgesia: low dose (0.5mg/kg tizanidine and 2.0 mg/kg baclofen), mid dose (1.5 mg/kg tizanidine and 5.0 mg/kg baclofen), and high dose(3.0 mg/kg tizanidine and 6.0 mg/kg baclofen. (Abstract shortened by UMI.) en_US
dc.format.extent 5461252 bytes
dc.format.extent 184 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language en en_US
dc.language.iso en_US
dc.title The relative effects of tizanidine and baclofen on sensorimotor function in rats en_US Physiology en_US Master of Science (M.Sc.) en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

View Statistics