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Localization of a sub-population of commissural cells active in treadmill locomotion in the adult rat thoracolumbar spinal cord

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dc.contributor.author Narotam, Nalini en_US
dc.date.accessioned 2007-05-18T12:14:18Z
dc.date.available 2007-05-18T12:14:18Z
dc.date.issued 1998-12-01T00:00:00Z en_US
dc.identifier.uri http://hdl.handle.net/1993/1610
dc.description.abstract The aim of this study was to identify a selective population of commissural neurons in the adult rat spinal cord that were active during treadmill locomotion. Fluorogold, a retrograde neuroanatomical tracer was combined with the immunocytochemical localization of the activity dependant cellular marker c-fos protein in an in vivo animal. We observed that the commissural neurons that were activated during locomotion are distributed from spinal segments T13 to L6. They are located primarily in Rexed's laminae VII & X of the intermediate zone and lamina VIII of the ventral horn. No c-fos and fluorogold double labeled cells were observed in the experimental animals that did not perform the treadmill locomotor task. This suggests that the identified neurons are specifically activated by the locomoter task. We also observed that ipsi-lateral propriospinal cells, known to have extensive synaptic connections within the spinal cord, were also active during treadmill locomotion. These identified commissural cells are active during physiological locomotion and they may mediate left/right alternating rhythmic patterns and represent an important component of the spinal central pattern generator (CPG). en_US
dc.format.extent 5727152 bytes
dc.format.extent 184 bytes
dc.format.mimetype application/pdf
dc.format.mimetype text/plain
dc.language en en_US
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.title Localization of a sub-population of commissural cells active in treadmill locomotion in the adult rat thoracolumbar spinal cord en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Physiology en_US
dc.degree.level Master of Science (M.Sc.) en_US


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