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dc.contributor.author Collins, Sorcha A
dc.contributor.author Surmala, Padma
dc.contributor.author Osborne, Geraldine
dc.contributor.author Greenberg, Cheryl
dc.contributor.author Bathory, Laakkuluk W
dc.contributor.author Edmunds-Potvin, Sharon
dc.contributor.author Arbour, Laura
dc.date.accessioned 2012-12-31T20:07:15Z
dc.date.available 2012-12-31T20:07:15Z
dc.date.issued 2012-12-12
dc.identifier.citation BMC Pediatrics. 2012 Dec 12;12(1):190
dc.identifier.uri http://hdl.handle.net/1993/14389
dc.description.abstract Abstract Background The northern territory Nunavut has Canada’s largest jurisdictional land mass with 33,322 inhabitants, of which 85% self-identify as Inuit. Nunavut has rates of infant mortality, postneonatal mortality and hospitalisation of infants for respiratory infections that greatly exceed those for the rest of Canada. The infant mortality rate in Nunavut is 3 times the national average, and twice that of the neighbouring territory, the Northwest Territories. Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections. Methods To determine the causes and potential risk factors of infant mortality in Nunavut, we reviewed all infant deaths (<1yr) documented by the Nunavut Chief Coroner’s Office and the Nunavut Bureau of Statistics (n=117; 1999–2011). Rates were compared to published data for Canada. Results Sudden death in infancy (SIDS/SUDI; 48%) and infection (21%) were the leading causes of infant death, with rates significantly higher than for Canada (2003–2007). Of SIDS/SUDI cases with information on sleep position (n=42) and bed-sharing (n=47), 29 (69%) were sleeping non-supine and 33 (70%) were bed-sharing. Of those bed-sharing, 23 (70%) had two or more additional risk factors present, usually non-supine sleep position. CPT1A P479L homozygosity, which has been previously associated with infant mortality in Alaska Native and British Columbia First Nations populations, was associated with unexpected infant death (SIDS/SUDI, infection) throughout Nunavut (OR:3.43, 95% CI:1.30-11.47). Conclusion Unexpected infant deaths comprise the majority of infant deaths in Nunavut. Although the CPT1A P479L variant was associated with unexpected infant death in Nunavut as a whole, the association was less apparent when population stratification was considered. Strategies to promote safe sleep practices and further understand other potential risk factors for infant mortality (P479L variant, respiratory illness) are underway with local partners.
dc.title Causes and risk factors for infant mortality in Nunavut, Canada 1999¿2011
dc.type Journal Article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Sorcha A Collins et al.; licensee BioMed Central Ltd.
dc.date.updated 2012-12-31T20:07:15Z
dc.identifier.doi http://dx.doi.org/10.1186/1471-2431-12-190


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