Vakaniaki, Emmanuel H.Merritt, SydneyLinsuke, SylvieMalembi, EmileMuyembe, FranciscaLunyanga, LygieMayuma, AndreaKwete, PapyKalonji, ThierryMadinga, JouleLeBreton, MatthewNakoune, EmmanuelKalthan, ErnestShang, SevidzemNwobegahay, JuliusEhiakhamen, OdianosenDibongue, ElsaKankou, Jean-MédardErima, BernardByarugaba, Denis K.Kinzie, Paige R.Mebwa, FranckBaelongandi, FrancisKayolo, AiméNabugobe, PépinMwamba, DieudonnéMalekani, JeanNguete, BeatriceKaba, DidineHensley, Lisa E.Kindrachuk, JasonLiesenborghs, LaurensShongo, RobertMuyembe-Tamfum, Jean-JacquesHoff, Nicole A.Rimoin, Anne W.Mbala-Kingebeni, Placide2025-04-042025-04-042025-03-05Global Health Research and Policy. 2025 Mar 05;10(1):14http://hdl.handle.net/1993/38985Abstract To address the underreporting of mpox cases in endemic regions, a regional surveillance network, known as the Mpox Threat Reduction Network (MPX-TRN), was established between five neighboring countries in Central and West Africa in 2022. One direct outcome of the MPX-TRN has been the strengthening of regional mpox surveillance. This consortium has facilited open communication channels, detection of cross-border mpox cases, and improvements of the detection and diagnosis of mpox in Central Africa and worldwide. Importantly, the MPX-TRN provides a scalable model for addressing underreporting of diseases, such as mpox.engMpoxMonkeypoxRegional surveillance networkShared experienceThe Democratic Republic of Congojournal articleThe Author(s)2025-04-0110.1186/s41256-025-00408-y