Li, JiangLin, FrancisLi, LingdongLi, JingLiu, Song2018-10-092018-10-092012-05-082018-10-05Li, J.; Lin, F.; Li, L.; Li, J.; Liu, S.* Surface engineering of poly(ethylene terephthalate) for durable hemocompatibility via a surface interpenetrating network technique. Macromolecular Chemistry and Physics, 2012; 213(20): 2120–2129.http://hdl.handle.net/1993/33530Heparin was covalently bonded on chemically inert PET substrate using a surface modifi cation technique–surface interpenetrating network with the purpose of fabricating long-lasting biocompatible materials as vascular grafts. FTIR and XPS spectra confi rmed the successful heparinization of PET (PET-Hep). The density of surface-immobilized heparin as quantifi ed by a colorimetric method could reach 2.4 μ g cm − 2 (in the reported optimal range: 1.5–3.0 μ g cm − 2 ). The hemocompatibility of the heparin-immobilized PET was improved as evidenced by a platelet adhesion test: signifi cantly less platelet adhesion on PET-Hep (11.60%) than on untreated PET (48.91%). An MTT assay indicated PET-Hep was nontoxic to human dermal fi broblast cells. After an initial 5.24% loss of heparin from PETHep in the fi rst 14 h immersion in PBS buffer solution, no further leaching of heparin was found.engSurface Engineering of Poly(ethylene terephthalate)Surface Interpenetrating NetworkDurable HemocompatibilityArticle10.1002/macp.201200251