Sedigheh, Nazaripour2016-09-202016-09-202016http://hdl.handle.net/1993/31828A new pH sensitive polyurethane intravaginal ring reservoir (PU Res IVR) drug delivery system was developed using a novel and versatile method. A combination of surface-initiated activator regenerated by electron transfer atom transfer radical polymerization (SI-ARGET-ATRP) and alkyne-azide click reaction was applied to graft pH sensitive polymers with different functional groups from the surface of PU Res IVR segments. Release studies showed that the dominant mechanism is " the through pore mechanism" in this system.engpH Responsive, Polymer Brushes, Intravagianl Ring, Stimuli-Responsive,master thesis