Extensive evidence supports a role for polyclonal serum natural antibody (NAb) acting as a mediator of natural resistance against tumors in mice. However, little is known about its mechanisms of action or about the phenotype ...

Previous studies using a murine F1-hybrid model of acute GVHD have shown that mortality is prevented if the graft is depleted of NK1.1 + cells. The precise role played by these cells in the pathogenesis of GVHD has not ...

The aim of the present study was to elucidate the role of regulatory type 1 cytokines, particularly IL-12 and IFN-[gamma] in the mechanisms by which the immune responses are suppressed or augmented. The hypothesis was that ...

Antiestrogenic drugs tamoxifen (TX) and toremifene (TO) are known to augment immune cytolysis in tumor targets induced by various killer cells. Here, we show that antiestrogens are capable of enhancing natural killer (NK) ...

The College of Physicians and Surgeons of Manitoba, the Canadian Medical Association, and the Society of Obstetricians and Gynecologists of Canada have recommended that HIV screening be offered to all pregnant women ...

Background: Caveolin-1 (Cav-1), the major component of caveolae, is a multifunctional scaffolding protein that serves as a platform for the cell’s signal-transduction and plays a role in inflammation. However, its role in ...

Myeloid-derived suppressor cells (MDSCs), characterized by the co-expression of CD11b and Gr1, are a heterogeneous population of immature myeloid cells that exhibit strong suppressive functions against T cell responses. ...

Lassa virus (LASV) is the causative agent of a hemorrhagic fever endemic in West Africa, which results in over 200,000 infections and 3000 to 5000 deaths annually. It has previously been demonstrated that a live attenuated ...