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dc.contributor.supervisor Bridges, Greg (Electrical and Computer Engineering) en
dc.contributor.author Salimi, Elham
dc.date.accessioned 2011-04-07T19:30:17Z
dc.date.available 2011-04-07T19:30:17Z
dc.date.issued 2011-04-07T19:30:17Z
dc.identifier.uri http://hdl.handle.net/1993/4460
dc.description.abstract Nanosecond pulse electroporation of biological cells is gaining significant interest due to its ability to influence intracellular structures. In nanosecond pulse electroporation of biological cells nanosecond duration pulses with high frequency spectral content are applied to the cell. In this research we show that accurate modeling of the nanosecond pulse electroporation process requires considering the effect of the membrane dielectric relaxation on the electric potential across the membrane. We describe the dielectric relaxation of the membrane as dispersion in the time-domain and incorporate it into the nonlinear asymptotic model of electroporation. Our nonlinear dispersive model of a biological cell is solved using finite element method in 3-D space enabling arbitrary cell structures and internal organelles to be modeled. The simulation results demonstrate two essential differences between dispersive and non-dispersive membrane models: the process of electroporation occurs faster when the membrane dispersion is considered, and the minimum required electric field to electroporate the cell is significantly reduced for the dispersive model. en
dc.format.extent 681020 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Electroporation en
dc.subject Dielectric dispersion en
dc.subject Debye relaxation model en
dc.title Nanosecond pulse electroporation of biological cells: The effect of membrane dielectric relaxation en
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Electrical and Computer Engineering en
dc.contributor.examiningcommittee Thomson, Douglas (Electrical and Computer Engineering) Lin, Francis (Physics and Astronomy) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note May 2011 en


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