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dc.contributor.supervisor Nyachoti, Martin (Animal Science) en_US
dc.contributor.author NDOU, SAYMORE PETROS
dc.date.accessioned 2019-01-07T17:18:25Z
dc.date.available 2019-01-07T17:18:25Z
dc.date.issued 2018-12-18 en_US
dc.date.submitted 2018-12-18T17:41:51Z en
dc.identifier.uri http://hdl.handle.net/1993/33627
dc.description.abstract In recent years, the use of agro-industrial co-products has significantly increased in pig diets resulting in increased dietary fiber. It is, however, intriguing that nutrient utilization and performance are depressed if pigs consume nutritionally balanced high-fiber diets that are composed of co-products plus supplementary fat. The first study indicated that addition of soluble fiber from Flaxseed meal (FM) and insoluble fiber from Oat hulls (OH) in pig diets increased intestinal VFA and BA contents but reduced fecal fat digestibility and induced variable effects on the histological characteristics, and composition and function of digesta- and mucosa-associated microbiota in gastrointestinal segments. Moreover, soluble fiber from FM depressed growth performance. The second study showed that soluble fiber from FM and insoluble fiber from OH reduced, ileal digested energy, FA digestibility, and absorption, gastrointestinal flows of FA and excretion of BA and both dietary fiber sources induced variable effects on digestibility of DF fractions, hindgut VFA production and fecal flows of unsaturated FA. The third study investigated the interactive effects of DF solubility and lipid type on digestibility of DF and FA, and flows of FA and BA in the ileum, cecum and colon, and VFA production and absorption in the cecum and colon of growing pigs. The production and absorption of VFA and DF fermentability in the cecum and colon was greater in pigs fed soluble fiber from Pectin compared to those fed insoluble fiber from Cellulose, and beef tallow supplementation depressed fermentation compared to corn oil. The interaction between DF solubility and lipid type modulates digestibility of lipids, flows of FA and BA and fermentability of DF fractions but differs for soluble and insoluble fiber, and saturated and unsaturated fatty acids. Lastly, the fourth study revealed that soluble from FM and insoluble fiber from OH increased the VFA uptake, and transportation and induced comparable effects on expressions of mRNA of colonic and hepatic genes involved in lipid metabolism. Taken together, soluble and insoluble fiber reduce fatty acids digestibility and induce variable effects on growth performance, intestinal fermentation, histomorphology, expression of genes involved in lipid metabolism and gastrointestinal microbiota composition. en_US
dc.subject bile acids, dietary fiber, flaxseed meal, pigs, oat hulls, hindgut fermentation, volatile fatty acids, pectin, cellulose, short chain fatty acids, soluble fiber, insoluble fiber, fatty acids, dietary lipids en_US
dc.title Production, absorption, and metabolic fate of fatty acids in pigs fed high-fiber diets en_US
dc.degree.discipline Animal Science en_US
dc.contributor.examiningcommittee Slominski, Bogdan (Animal Science) Kiarie, Elijah(Animal Science) Ames, Nancy (Human Nutritional Sciences) Bach Knudsen, Knud Erik (Aarhus University, Denmark) en_US
dc.degree.level Doctor of Philosophy (Ph.D.) en_US
dc.description.note February 2019 en_US


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